Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.2.3 extracted from

  • Szilagyi, A.N.; Vas, M.
    Anion activation of 3-phosphoglycerate kinase requires domain closure (1998), Biochemistry, 37, 8551-8563.
    View publication on PubMed
Search for more literature for 2.7.2.3

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme is regulated by multivalent anions, overview Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1,5-Bisphosphonopentane competitive Sus scrofa
2,3-diphosphoglycerate
-
 Sus scrofa
2-Phosphoglycolate competitive Sus scrofa
adenosine
-
 Sus scrofa
Glycerol 2-phosphate competitive Sus scrofa
glycerol 3-phosphate competitive Sus scrofa
additional information double-inhibition studies, kinetics, modeling of inhibitor binding, e.g. phosphate; enzyme is regulated by multivalent anions, overview Sus scrofa
phosphate
-
 Sus scrofa
SO42-
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
 Sus scrofa ADP + 1,3-diphosphoglycerate
-
 r
additional information enzyme is regulated by multivalent anions Sus scrofa ?
-
 ?
additional information 2-domain hinge-binding enzyme Sus scrofa ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Sus scrofa
ATP required as phosphate donor Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.35
-
 2,3-diphosphoglycerate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
0.7
-
 glycerol 3-phosphate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
4
-
 2-Phosphoglycolate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
8.3
-
 phosphate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
9.6
-
 Glycerol 2-phosphate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
14
-
 sulfate pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa
26
-
 1,5-Bisphosphonopentane pH 7.5, 20°C, versus 3-phospho-D-glycerate Sus scrofa