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Literature summary for 2.7.2.3 extracted from
- The anatomy of a kinase and the control of phosphate transfer (1993), Eur. J. Biochem., 216, 1-18.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| (NH4)2SO4 | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae |  |
| ATP4- | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| Sodium citrate | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| Sodium selenate | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| Sodium succinate | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (NH4)2SO4 | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| 1,3-bisphosphoglycerate | - |
Equus caballus | |
| 1,3-bisphosphoglycerate | - |
Saccharomyces cerevisiae | |
| 1,3-bisphosphoglycerate | - |
Sus scrofa | |
| 3-phospho-D-glycerate | - |
Equus caballus | |
| 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | |
| 3-phospho-D-glycerate | - |
Sus scrofa | |
| ATP4- | - |
Equus caballus | |
| ATP4- | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| ATP4- | - |
Sus scrofa | |
| gallic acid | - |
Equus caballus | |
| gallic acid | - |
Saccharomyces cerevisiae | |
| gallic acid | - |
Sus scrofa | |
| inositol triphosphate | - |
Equus caballus | |
| inositol triphosphate | - |
Saccharomyces cerevisiae | |
| inositol triphosphate | - |
Sus scrofa | |
| KH2PO4 | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| MK-401 | - |
Equus caballus | |
| MK-401 | - |
Saccharomyces cerevisiae | |
| MK-401 | - |
Sus scrofa | |
| NaCl | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| NaNO2 | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| phosphate | - |
Equus caballus | |
| phosphate | - |
Saccharomyces cerevisiae | |
| phosphate | - |
Sus scrofa | |
| SO42- | - |
Equus caballus | |
| SO42- | - |
Saccharomyces cerevisiae | |
| SO42- | - |
Sus scrofa | |
| Sodium citrate | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| Sodium selenate | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| Sodium succinate | inhibition at high concentration, activation at low concentrations | Saccharomyces cerevisiae | |
| sulphasalazine | - |
Equus caballus | |
| sulphasalazine | - |
Saccharomyces cerevisiae | |
| sulphasalazine | - |
Sus scrofa | |
| [Co(CN)6]3- | - |
Equus caballus | |
| [Co(CN)6]3- | - |
Saccharomyces cerevisiae | |
| [Co(CN)6]3- | - |
Sus scrofa | |
| [Fe(CN)6]3- | - |
Equus caballus | |
| [Fe(CN)6]3- | - |
Saccharomyces cerevisiae | |
| [Fe(CN)6]3- | - |
Sus scrofa | |
| [Fe(CN)6]4- | - |
Equus caballus | |
| [Fe(CN)6]4- | - |
Saccharomyces cerevisiae | |
| [Fe(CN)6]4- | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Sus scrofa | |
| additional information | - |
additional information | kinetics | Saccharomyces cerevisiae | |
| additional information | - |
additional information | kinetics | Equus caballus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| KH2PO4 | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| Mg2+ | required | Sus scrofa | |
| Mg2+ | required | Saccharomyces cerevisiae | |
| Mg2+ | required | Equus caballus | |
| Mg2+ | true substrate is the magnesium complexes of ATP | Sus scrofa | |
| Mg2+ | true substrate is the magnesium complexes of ATP | Saccharomyces cerevisiae | |
| Mg2+ | true substrate is the magnesium complexes of ATP | Equus caballus | |
| NaCl | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
| NaNO2 | inhibition at high concentration, acceleration of activity at low concentrations | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + 3-phospho-D-glyceroyl phosphate | Sus scrofa | responsible for production of ATP during glycolysis | ATP + 3-phospho-D-glycerate | - |
r | |
| ADP + 3-phospho-D-glyceroyl phosphate | Saccharomyces cerevisiae | responsible for production of ATP during glycolysis | ATP + 3-phospho-D-glycerate | - |
r | |
| ADP + 3-phospho-D-glyceroyl phosphate | Equus caballus | responsible for production of ATP during glycolysis | ATP + 3-phospho-D-glycerate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
| Saccharomyces cerevisiae | - |
normal and various site-specific mutant forms | - |
| Sus scrofa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate | mechanism | Sus scrofa | |
| ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate | mechanism | Saccharomyces cerevisiae | |
| ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate | mechanism | Equus caballus | |
| ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate | substrate binding | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + 3-phospho-D-glyceroyl phosphate | responsible for production of ATP during glycolysis | Sus scrofa | ATP + 3-phospho-D-glycerate | - |
r | |
| ADP + 3-phospho-D-glyceroyl phosphate | responsible for production of ATP during glycolysis | Saccharomyces cerevisiae | ATP + 3-phospho-D-glycerate | - |
r | |
| ADP + 3-phospho-D-glyceroyl phosphate | responsible for production of ATP during glycolysis | Equus caballus | ATP + 3-phospho-D-glycerate | - |
r | |
| ATP + 3-phospho-D-glycerate | - |
Sus scrofa | ADP + 1,3-diphosphoglycerate | - |
r | |
| ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 1,3-diphosphoglycerate | - |
r | |
| ATP + 3-phospho-D-glycerate | - |
Equus caballus | ADP + 1,3-diphosphoglycerate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | - |
Sus scrofa |
| More | overview: structure functioin relationship | Saccharomyces cerevisiae |
| More | overview: structure functioin relationship | Equus caballus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Sus scrofa |
| additional information | - |
- |
Equus caballus |
| additional information | - |
thermal analysis | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Sus scrofa | |
| ADP | true substrate is the magnesium complexes of ADP | Saccharomyces cerevisiae | |
| ADP | true substrate is the magnesium complexes of ADP | Equus caballus | |
| ATP | true substrate is the magnesium complexes of ATP | Sus scrofa | |
| ATP | true substrate is the magnesium complexes of ATP | Saccharomyces cerevisiae | |
| ATP | true substrate is the magnesium complexes of ATP | Equus caballus | |
| ATP | required as phosphate donor | Sus scrofa | |
| ATP | required as phosphate donor | Saccharomyces cerevisiae | |
| ATP | required as phosphate donor | Equus caballus | |
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