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Literature summary for 2.7.2.3 extracted from

  • Keith, A.; Parson, M.
    Characterization of a divergent glycosomal microbody phosphoglycerate kinase from Trypanosoma brucei (1993), Mol. Biochem. Parasitol., 60, 265-272.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
SO42- activation with yeast PGK, inhibition with Trypanosomal PGK Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
gene PGKA, expression in Escherichia coli deficient mutant as a fusion protein, complementation of the mutant phenotype Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
SO42- activation with yeast PGK, inhibition with trypanosomal PGK Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
ATP recombinant isozyme 56PGK Trypanosoma brucei
0.12
-
ATP ATP in form of MgATP2- Trypanosoma brucei
2.4
-
3-phospho-D-glycerate recombinant isozyme 56PGK Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
glycosome isozyme 56PGK, glycosomal microbody Trypanosoma brucei 20015
-

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
glycosomal isozyme 56PGK, gene PGKA
-
Trypanosoma brucei
-
cytoplasmic isozyme
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from Escherichia coli, to homogeneity Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
Trypanosoma brucei ADP + 1,3-diphosphoglycerate
-
r
ATP + 3-phospho-D-glycerate
-
Trypanosoma brucei ADP + 3-phospho-D-glyceroyl phosphate
-
r
GTP + 3-phospho-D-glycerate no activity Trypanosoma brucei GDP + 1,3-diphosphoglycerate
-
?
ITP + 3-phospho-D-glycerate no activity Trypanosoma brucei IDP + 1,3-diphosphoglycerate
-
?

Cofactor

Cofactor Comment Organism Structure
ADP
-
Trypanosoma brucei
ATP required as phosphate donor Trypanosoma brucei