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Literature summary for 2.7.2.11 extracted from

  • Fujita, T.; Maggio, A.; Garcia-Rios, M.; Stauffacher, C.; Bressan, R.A.; Csonka, L.N.
    Identification of regions of the tomato gamma-glutamyl kinase that are involved in allosteric regulation by proline (2003), J. Biol. Chem., 278, 14203-14210.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A62T drastic reduction in specific activity. 911fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
A62V drastic reduction in specific activity. 188fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
D147G reduction in catalytic activity. 2000fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
D162G drastic reduction in specific activity. 611.1fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
D162N drastic reduction in specific activity. 644fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
E153A reduction in catalytic activity. 555.5fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
E153G reduction in catalytic activity. 555.5fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
E153K reduction in catalytic activity. 3444.4fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
I149F drastic reduction in specific activity. 222.2fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
I149F 222.2fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
I79T reduction in catalytic activity. 21.1fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
L154S reduction in catalytic activity. 1000fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
M94T reduction in catalytic activity. 255.6fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum
S159P reduction in catalytic activity. 211.1fold increase in Ki-value for L-Pro compared to wild-type enzyme Solanum lycopersicum

Inhibitors

Inhibitors Comment Organism Structure
L-Pro
-
Solanum lycopersicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate Solanum lycopersicum
-
ADP + L-glutamate 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Solanum lycopersicum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate
-
Solanum lycopersicum ADP + L-glutamate 5-phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.09
-
L-Pro wild-type enzyme Solanum lycopersicum
1.9
-
L-Pro mutant enzyme I79T Solanum lycopersicum
17
-
L-Pro mutant enzyme A62V Solanum lycopersicum
19
-
L-Pro mutant enzyme S159P Solanum lycopersicum
20
-
L-Pro mutant enzyme I149F Solanum lycopersicum
23
-
L-Pro mutant enzyme M94T Solanum lycopersicum
50
-
L-Pro mutant enzyme E153A or E153G Solanum lycopersicum
55
-
L-Pro mutant enzyme D162G Solanum lycopersicum
58
-
L-Pro mutant enzyme D162N Solanum lycopersicum
82
-
L-Pro mutant enzyme A62T Solanum lycopersicum
90
-
L-Pro mutant enzyme L154S Solanum lycopersicum
180
-
L-Pro mutant enzyme D147G Solanum lycopersicum
310
-
L-Pro mutant enzyme E153K Solanum lycopersicum