Literature summary for 2.7.2.1 extracted from

Tiwari, S.; Barh, D.; Imchen, M.; Rao, E.; Kumavath, R.K.; Seenivasan, S.P.; Jaiswal, A.K.; Jamal, S.B.; Kumar, V.; Ghosh, P.; Azevedo, V.
Acetate kinase (AcK) is essential for microbial growth and betel-derived compounds potentially target AcK, PhoP and MDR proteins in M. tuberculosis, V. cholerae and pathogenic E. coli an in silico and in vitro study (2018), Curr. Top. Med. Chem., 18, 2731-2740 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli DH5alpha cells	Mycobacterium tuberculosis
expressed in Escherichia coli DH5alpha cells	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
6-oxopiperidine-3-carboxylic acid	82.6% inhibition at 70 mM	Escherichia coli
6-oxopiperidine-3-carboxylic acid	-	Mycobacterium tuberculosis
chlorogenic acid	58.74% inhibition at 70 mM	Escherichia coli
chlorogenic acid	-	Mycobacterium tuberculosis
eugenyl acetate	66.52% inhibition at 70 mM	Escherichia coli
additional information	not inhibited by eugenyl acetate and pinoresinol	Mycobacterium tuberculosis
pinoresinol	82.6% inhibition at 70 mM	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + acetate	Mycobacterium tuberculosis	-	ADP + acetyl phosphate	-	?
ATP + acetate	Escherichia coli	-	ADP + acetyl phosphate	-	?
ATP + acetate	Mycobacterium tuberculosis H37Rv	-	ADP + acetyl phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A6A5	-	-
Mycobacterium tuberculosis	P9WQH1	-	-
Mycobacterium tuberculosis H37Rv	P9WQH1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acetate	-	Mycobacterium tuberculosis	ADP + acetyl phosphate	-	?
ATP + acetate	-	Escherichia coli	ADP + acetyl phosphate	-	?
ATP + acetate	-	Mycobacterium tuberculosis H37Rv	ADP + acetyl phosphate	-	?

Synonyms

Synonyms	Comment	Organism
ACK	-	Mycobacterium tuberculosis
ACK	-	Escherichia coli

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Release 2023.1 (January 2023)