Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.13.3 extracted from

  • Gendrin, C.; Lembo, A.; Whidbey, C.; Burnside, K.; Berry, J.; Ngo, L.; Banerjee, A.; Xue, L.; Arrington, J.; Doran, K.S.; Tao, W.A.; Rajagopal, L.
    The sensor histidine kinase RgfC affects group B streptococcal virulence factor expression independent of its response regulator RgfA (2015), Infect. Immun., 83, 1078-1088.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.13.3

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae A0A8G2N576 belongs to the group B streptococci, strains A909 and COH1 are clinical isolates belonging to capsular polysaccharide serotype 1a and serotype III, respectively
-

Synonyms

Synonyms Comment Organism
RgfC
-
 Streptococcus agalactiae
sensor histidine kinase
-
 Streptococcus agalactiae

General Information

General Information Comment Organism
malfunction group B streptococci deficient in RgfC expression exhibit increased virulence, deletion of rgfC in group B streptococci strains lacking a functional RgfA increased systemic infection. Infection with the rgfC mutant increases induction of proinflammatory signaling pathways in vivo. 19 phosphopeptides corresponding to 12 proteins are differentially phosphorylated at aspartate, cysteine, serine, threonine, or tyrosine residues in the rgfC mutant. This includes aspartate phosphorylation of a tyrosine kinase, CpsD, and a transcriptional regulator. Over 200 genes show altered expression compared to the isogenic wild-type strain and included transcriptional regulators, transporters, and genes previously associated with group B streptococci pathogenesis. In the absence of RgfA, nonspecific RgfC signaling affects the expression of virulence factors and GBS pathogenesis. Sialic acid levels are higher in the DELTArgfCAd mutant than in wild-type A909, correlated with an increase in gene expression of the capsular polysaccharide operon. Sialylation of the group B streptococci capsular polysaccharide is critical for group B streptococci bloodstream infections and pathogenesis Streptococcus agalactiae
physiological function the two-component system comprising the sensor histidine kinase RgfC and the response regulator RgfA mediate GBS binding to extracellular matrix components, such as fibrinogen. The sensor histidine kinase RgfC is involved in gene regulation in group B streptococci and affects group B streptococcal virulence factor expression independent of its response regulator RgfA. Enzyme RgfC regulates expression of capsular polysaccharide and serine protease genes in GBS A909. RgfC functions as a nonspecific or orphan kinase in group B streptococci strains Streptococcus agalactiae