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Literature summary for 2.7.13.3 extracted from

  • Scott, D.R.; Marcus, E.A.; Wen, Y.; Singh, S.; Feng, J.; Sachs, G.
    Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4+, is necessary for acid survival of Helicobacter pylori (2010), J. Bacteriol., 192, 94-103.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Helicobacter pylori 5737
-

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Synonyms

Synonyms Comment Organism
HP0165
-
 Helicobacter pylori
HP0244
-
 Helicobacter pylori
sensor histidine kinase
-
 Helicobacter pylori

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Helicobacter pylori

General Information

General Information Comment Organism
malfunction HP0244 deletion abolishes urease activation and assembly, impairs cytoplasmic and periplasmic pH homeostasis, and depolarizes the cells, with an about 7-log loss of survival at pH 2.5, even in 10 mM urea Helicobacter pylori
physiological function HP0244 is required for inner membrane assembly of UreA, UreB, and UreE and for urease activity Helicobacter pylori