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Literature summary for 2.7.13.3 extracted from

  • Li, N.; Wang, F.; Niu, S.; Cao, J.; Wu, K.; Li, Y.; Yin, N.; Zhang, X.; Zhu, W.; Yin, Y.
    Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK) (2009), BMC Microbiol., 9, 129.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
2-(3,4-dimethoxyphenyl)-N-[(5-phenylfuran-2-yl)methyl]ethanaminium
-
Streptococcus pneumoniae
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[4-(thiophen-2-ylmethoxy)benzyl]ethanaminium
-
Streptococcus pneumoniae
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[[5-(3-chloro-4-methoxyphenyl)furan-2-yl]methyl]ethanaminium
-
Streptococcus pneumoniae
N,N'-bis(1H-benzimidazol-2-yl)biphenyl-4,4'-diamine
-
Streptococcus pneumoniae
N-[[5-(2-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
Streptococcus pneumoniae
N-[[5-(3-chloro-4-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae Q9S1J9
-
-
Streptococcus pneumoniae D39 / ATCC 7466 Q9S1J9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + VicR protein L-histidine
-
Streptococcus pneumoniae ADP + VicR protein N-phospho-L-histidine
-
?
ATP + VicR protein L-histidine
-
Streptococcus pneumoniae D39 / ATCC 7466 ADP + VicR protein N-phospho-L-histidine
-
?

Synonyms

Synonyms Comment Organism
VicK
-
Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Streptococcus pneumoniae