Literature summary for 2.7.13.3 extracted from

Wen, Y.; Feng, J.; Scott, D.R.; Marcus, E.A.; Sachs, G.
The pH responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori (2008), J. Bacteriol., 191, 449-460.

Cloned(Commentary)

Cloned (Comment)	Organism
profiling of a HP0244 deletion mutant grown at pH 7.4, contribution of HP0244 to sigma(54) activation via HP0703 to coordinate flagellar biosynthesis by a pH-independent regulon that includes 14 flagellar genes. Microarray analysis of cells grown at pH 4.5 without urea reveals an additional 22 genes, including 4 acid acclimation genes, e.g. ureA, ureB, ureI, and amiE, that are positively regulated by HP0244, overview	Helicobacter pylori

Cloned (Comment)

Organism

profiling of a HP0244 deletion mutant grown at pH 7.4, contribution of HP0244 to sigma(54) activation via HP0703 to coordinate flagellar biosynthesis by a pH-independent regulon that includes 14 flagellar genes. Microarray analysis of cells grown at pH 4.5 without urea reveals an additional 22 genes, including 4 acid acclimation genes, e.g. ureA, ureB, ureI, and amiE, that are positively regulated by HP0244, overview

Helicobacter pylori

Protein Variants

Protein Variants	Comment	Organism
additional information	an acid survival study using an HP0703 mutant and an electrophoretic mobility shift assay with in vitro-phosphorylated HP0703 showe, that HP0703 does not contribute to acid survival and does not bind to the promoter regions of several genes in the HP0244 pH-dependent regulon, suggesting that there is a pathway outside the HP0703 regulon which transduces the acid-responsive signal sensed by HP0244	Helicobacter pylori

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Helicobacter pylori	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Helicobacter pylori	the enzyme HP0244 is not only required to regulate flagellar gene expression via its cognate response regulator, HP0703, but also to generate a response to declining medium pH. Although not required for survival at pH 4.5, HP0244 is required for survival at pH 2.5, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	O25026	gene HP0244	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme HP0244 is not only required to regulate flagellar gene expression via its cognate response regulator, HP0703, but also to generate a response to declining medium pH. Although not required for survival at pH 4.5, HP0244 is required for survival at pH 2.5, overview	Helicobacter pylori	?	-	?

Synonyms

Synonyms	Comment	Organism
FlgS	-	Helicobacter pylori
HP0244	-	Helicobacter pylori