Cloned (Comment) | Organism |
---|---|
gene MKK4, maps to chromosome 17p11.2 and encodes a 399-amino acid protein in humans spans over 120 kb and consists of 11 exons, for identification of the genetic effects of the -1304T>G polymorphism on cancer risk, a meta-analysis composed of the publications evaluating the association between the -1304T>G polymorphism and risk of cancer is performed, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | association between -1304T>G (rs3826392) polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in a southern Chinese population | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P45985 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute myeloid leukemia cell | - |
Homo sapiens | - |
cervical cancer cell | - |
Homo sapiens | - |
colon cancer cell | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
esophageal cancer cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
nasopharyngeal carcinoma cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
JNKK1 | - |
Homo sapiens |
MAP2K4 | - |
Homo sapiens |
MEK4, | - |
Homo sapiens |
mitogen-activated protein kinase kinase 4 | - |
Homo sapiens |
MKK4 | - |
Homo sapiens |
SEK1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the MAP kinase family | Homo sapiens |
malfunction | MKK4 is highly mutated and has a pro-oncogenic role in cancers of pancreatic, breast, colon, prostate, skin, and laryngeal squamous cell. Strong association between -1304T>G (rs3826392) polymorphism in the promoter of MKK4 gene and a decreased risk of sporadic colorectal cancer in a southern Chinese population, overview | Homo sapiens |
metabolism | MKK4 belongs to MAPK pathways known to have involvement in the regulation of apoptosis, inflammation, and tumorigenesis | Homo sapiens |
physiological function | the enzyme plays a key role in multiple physiologic and pathophysiologic processes such as inflammation and tumor suppression | Homo sapiens |