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Literature summary for 2.7.12.2 extracted from

  • Ripple, M.; Kim, N.; Springett, R.
    Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation (2013), J. Biol. Chem., 288, 2933-2940.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Inhibitors

Inhibitors Comment Organism Structure
MIIC i.e. MEK inhibitor I, the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption; i.e. MEK inhibitor I, the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption Homo sapiens
additional information design of small molecule MEK1/2 inhibitors to block ERK1/2-mediated signaling and inhibit proliferation. Four structurally distinct MEK1/2 inhibitors acutely affect mitochondrial bioenergetics. The anti-mitochondrial effects of MEK1/2 inhibitors determine the proliferative potential; design of small molecule MEK1/2 inhibitors to block ERK1/2-mediated signaling and inhibit proliferation. Four structurally distinct MEK1/2 inhibitors acutely affect mitochondrial bioenergetics. The anti-mitochondrial effects of MEK1/2 inhibitors determine the proliferative potential Homo sapiens
PD198306 an orally active MEK1/2 inhibitor, acting as an uncoupler; an orally active MEK1/2 inhibitor, acting as an uncoupler Homo sapiens
PD98059 the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption; the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption Homo sapiens
U0126 the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption; the MEK1/2 inhibitor causes NAD(H) reduction, heme oxidation, and decreased oxygen consumption Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ERK1 Homo sapiens phosphorylation of extracellular signal-regulated kinase 1 ADP + phosphorylated ERK1
-
 ?
ATP + ERK2 Homo sapiens phosphorylation of extracellular signal-regulated kinase 2 ADP + phosphorylated ERK2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P36507
-
-
Homo sapiens Q02750
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK1 phosphorylation of extracellular signal-regulated kinase 1 Homo sapiens ADP + phosphorylated ERK1
-
 ?
ATP + ERK2 phosphorylation of extracellular signal-regulated kinase 2 Homo sapiens ADP + phosphorylated ERK2
-
 ?

Synonyms

Synonyms Comment Organism
MEK1
-
 Homo sapiens
MEK2
-
 Homo sapiens
mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1
-
 Homo sapiens
mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens