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Literature summary for 2.7.12.2 extracted from

  • Yan, L.; Yang, Q.; Sundin, G.W.; Li, H.; Ma, Z.
    The mitogen-activated protein kinase kinase BOS5 is involved in regulating vegetative differentiation and virulence in Botrytis cinerea (2010), Fungal Genet. Biol., 47, 753-760.
    View publication on PubMed
Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment) Organism
gene bos5 Botrytis cinerea

Protein Variants

Protein Variants Comment Organism
additional information generation of a bos5 gene deletion mutant DELTAbcos5-21 by gene replacement using Agrobacterium tumefaciens strain C58C1, complementation of the bos5 deletion mutant DELTAbos5-21 pathogenicity test in cucumber leaves, the DELTAbos5-21 is unable to infect cucumber leaves at all overview Botrytis cinerea

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Botrytis cinerea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + BcSak1 Botrytis cinerea
-
 ADP + phosphorylated BcSak1
-
 ?
ATP + BcSak1 Botrytis cinerea 38B1
-
 ADP + phosphorylated BcSak1
-
 ?

Organism

Organism UniProt Comment Textmining
Botrytis cinerea I7FWY1 i.e. Botryotinia fuckeliana
-
Botrytis cinerea 38B1 I7FWY1 i.e. Botryotinia fuckeliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + BcSak1
-
 Botrytis cinerea ADP + phosphorylated BcSak1
-
 ?
ATP + BcSak1 protei BcSAK1 is the putative downstream component of BOS5 Botrytis cinerea ADP + phosphorylated BcSak1
-
 ?
ATP + BcSak1
-
 Botrytis cinerea 38B1 ADP + phosphorylated BcSak1
-
 ?
ATP + BcSak1 protei BcSAK1 is the putative downstream component of BOS5 Botrytis cinerea 38B1 ADP + phosphorylated BcSak1
-
 ?

Synonyms

Synonyms Comment Organism
BcOs4
-
 Botrytis cinerea
BOS5
-
 Botrytis cinerea
MAPKK
-
 Botrytis cinerea
mitogen-activated protein kinase kinase
-
 Botrytis cinerea

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Botrytis cinerea

General Information

General Information Comment Organism
evolution bos5 from Botrytis cinerea, a gene that encodes a mitogen-activated protein kinase kinase (MAPKK), is homologous to OS-5 of Neurospora crassa Botrytis cinerea
malfunction the bos5 gene deletion mutant exhibits reduced vegetative growth and strongly impaired conidiation. The mutant also exhibits increased sensitivity to the dicarboximide fungicide iprodione and to osmotic stress mediated by NaCl or KCl. The BcSAK1 protein, the putative downstream component of BOS5, is not phosphorylated in the mutant. Plant inoculation tests show that the mutants are unable to infect cucumber leaves. All of these defects are restored by genetic complementation of the DELTAbcos5-21 mutant with the wild-type bos5 gene Botrytis cinerea
physiological function the mitogen-activated protein kinase kinase BOS5 is involved in regulating vegetative differentiation and virulence in Botrytis cinerea Botrytis cinerea