Cloned (Comment) | Organism |
---|---|
transient overexpression of MEKK-1 in insulin-producing cell lines RIN-5AH and betaTC-6 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of MEKK-1 in betaTC-6 and human dispersed islet cells by siRNA results in protection from DETA/NO, streptozotocin, H2O2, and tunicamycin induced cell death, transient overexpression of MEKK-1 in insulin-producing cell lines RIN-5AH and betaTC-6 leads to increase in c-Jun N-terminal kinase phosphorylation and augmented cell death induced by DETA/NO, streptozotocin, and H2O2, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | DETA/NO and streptozotocin induce rapid threonine phosphorylation of MEKK-1, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic islet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAPK kinase kinase-1 | - |
Homo sapiens |
MEKK-1 | - |
Homo sapiens |