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Literature summary for 2.7.12.2 extracted from

  • Mokhtari, D.; Myers, J.W.; Welsh, N.
    The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death (2008), Endocrinology, 149, 3046-3053.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient overexpression of MEKK-1 in insulin-producing cell lines RIN-5AH and betaTC-6 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of MEKK-1 in betaTC-6 and human dispersed islet cells by siRNA results in protection from DETA/NO, streptozotocin, H2O2, and tunicamycin induced cell death, transient overexpression of MEKK-1 in insulin-producing cell lines RIN-5AH and betaTC-6 leads to increase in c-Jun N-terminal kinase phosphorylation and augmented cell death induced by DETA/NO, streptozotocin, and H2O2, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein DETA/NO and streptozotocin induce rapid threonine phosphorylation of MEKK-1, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the MEKK-1 is involved in stress-induced cell death of insulin-producing cells and essential in JNK activation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MAPK kinase kinase-1
-
Homo sapiens
MEKK-1
-
Homo sapiens