Application | Comment | Organism |
---|---|---|
additional information | MKK4 promotes the survival of MEF cells by decreasing the expression of phosphatase and tensin homologue deleted from chromosome 10 PTEN. MKK4 inhibits PTEN transcription by activating NFkappaB, a transcriptional suppressor of PTEN. MKK4 is required for nuclear translocation of RelA/p65 and processing of the NFkappaB2 precursor p100 into the mature form p52. MKK4 promotes cell survival by activating phosphatidylinositol 3-kinase through an NFkappaB/PTEN-dependent pathway | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | MKK4-null MEF cells, are highly susceptible to apoptosis by LY294002, paclitaxel, or serum starvation. MKK4 loss increases PTEN expression and inhibits PI3K-dependent signaling but reveals persistent AKT phosphorylation in serum-starved MKK4-null cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment with LY294002, paclitaxel, or serum starvation does not induce apoptosis of wild-type MEF cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | - |
Mus musculus | - |
additional information | NSCLC cell lines H1299, H226B, H226Br, H332, H358, H460, A549, H596, and Calu-6 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
mitogen-activated protein kinase kinase-4 | - |
Mus musculus |
MKK4/SEK1 | - |
Mus musculus |