Application | Comment | Organism |
---|---|---|
medicine | novel isoform of human MKK7, is expressed in various normal tissues, tumors, and in synoviocytes from rheumatoid and osteoarthritis patients. Recombinant MKK7gamma1 can be phosphorylated and activated by MEKK1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
subcloned into the pET28b bacterial expression vector and expressed with a 6 x N-terminal His tag, also subcloned into pGEX 4T-3 for bacterial expression as a GST-fusion protein | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47940 | - |
sequence analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14733 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | weak expression | Homo sapiens | - |
breast carcinoma cell | strong expression | Homo sapiens | - |
CX-1 cell | medium expression | Homo sapiens | - |
heart | weak expression | Homo sapiens | - |
kidney | strongest expression in the human tissue panel | Homo sapiens | - |
liver | weak expression in adult and fetal liver | Homo sapiens | - |
lung | weak expression | Homo sapiens | - |
lung cancer cell | LX-1 cell, strong expression | Homo sapiens | - |
lymph node | strongest expression in human immune panel | Homo sapiens | - |
lymphocyte | peripheral blood, weak expression | Homo sapiens | - |
additional information | no expression in thymus, medium expression in GI-112 cell, weak expression in GI-117 cell | Homo sapiens | - |
ovary cancer cell | weak expression | Homo sapiens | - |
pancreas | weak expression | Homo sapiens | - |
pancreatic cancer cell | weak expression | Homo sapiens | - |
placenta | weak expression | Homo sapiens | - |
prostate adenocarcinoma cell | weak expression | Homo sapiens | - |
skeletal muscle | weak expression | Homo sapiens | - |
spleen | weak expression | Homo sapiens | - |
synovial tissue | isolated from osteoarthritis and rheumatoid arthritis patients | Homo sapiens | - |
tonsil | lowest expression in human immune panel | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + JNK1 | slight phosphorylation, JNK1 may not be the optimal substrate for the isoform | Homo sapiens | ADP + phosphorylated JNK1 | - |
? | |
additional information | MKK7gamma1 is unable to phosphorylate p38 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEKK1 | - |
Homo sapiens |
mitogen-activated protein kinase kinase 7gamma1 | - |
Homo sapiens |
MKK7gamma1 | - |
Homo sapiens |