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Literature summary for 2.7.12.2 extracted from

  • Karim, F.; Hu, H.J.; Adwanikar, H.; Kaplan, D.R.; Gereau, R.W.T.
    Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK) (2006), Mol. Pain, 2, 2.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Activating Compound

Activating Compound Comment Organism Structure
additional information ERK and MEK are activated by phosphorylation, ERK is induced by formalin Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information expression of the neuron-specific dominant negative mitogen activated protein kinase kinase in mutant mice leads to impaired inflammatory pain and thermal hyperalgesia Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
U0126 MEK inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ERK Mus musculus phosphorylation by MEK activates ERK, which plays a role in pain induction modulating the A-type currents of potassium channels in neurons, ERK plays a central role in nocireceptive sensitization in the spinal cord ADP + phosphorylated ERK
-
 ?
additional information Mus musculus the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein ERK and MEK are activated by phosphorylation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Mus musculus
-
spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK phosphorylation by MEK activates ERK, which plays a role in pain induction modulating the A-type currents of potassium channels in neurons, ERK plays a central role in nocireceptive sensitization in the spinal cord Mus musculus ADP + phosphorylated ERK
-
 ?
ATP + ERK ERK phosphorylation by MEK Mus musculus ADP + phosphorylated ERK
-
 ?
additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. formalin-induced inflammatory pain and thermal hyperalgesia, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ERK
-
 Mus musculus
extracellular signal-regulated kinase
-
 Mus musculus
MEK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus