Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-one | selective anthranilic acid type inhibitors, residues K97, I141, M143, F129, V127, I126, L118, F209, V211, and S212 of MEK1/2 are important for interaction with the inhibitor, noncompetitive to ATP, inhibition of ERK phosphorylation by MEK1/2 by the derivatives with IC50 values of 6.8-124 nM, low cytotoxic effects, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | Homo sapiens | ERK phosphorylation by MEK1/2 | ADP + phosphorylated ERK | - |
? | |
additional information | Homo sapiens | MEK1/2 are involved in the mitogen-activated protein kinase signaling pathway and in cancer tumorigenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | ERK phosphorylation by MEK1/2 | Homo sapiens | ADP + phosphorylated ERK | - |
? | |
additional information | MEK1/2 are involved in the mitogen-activated protein kinase signaling pathway and in cancer tumorigenesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEK 1 | - |
Homo sapiens |
MEK 2 | - |
Homo sapiens |
mitogen-activated protein kinase kinase 1 | - |
Homo sapiens |
mitogen-activated protein kinase kinase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000068 | 0.000124 | selective anthranilic acid type inhibitors, residues K97, I141, M143, F129, V127, I126, L118, F209, V211, and S212 of MEK1/2 are important for interaction with the inhibitor, noncompetitive to ATP, inhibition of ERK phosphorylation by MEK1/2 by the deriva | Homo sapiens | 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-one |