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Literature summary for 2.7.12.2 extracted from
- Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2 (1993), J. Biol. Chem., 268, 11435-11439.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P36507 | - |
- |
| Homo sapiens | Q02750 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ERK1 | MEK2 protein stimulates Thr and Tyr phosphorylation on ERK1 and concomitantly activates ERK1 kinase activity more than 100-fold | Homo sapiens | ADP + phosphorylated ERK1 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dual specificity mitogen-activated protein kinase kinase 1 | - |
Homo sapiens |
| dual specificity mitogen-activated protein kinase kinase 2 | - |
Homo sapiens |
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