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Literature summary for 2.7.12.2 extracted from
- Kinetic and catalytic mechanisms of protein kinases (2001), Chem. Rev., 101, 2271-2290.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | can partially substitue Mg2+ | eukaryota |  |
| Co2+ | can partially substitue Mg2+ | eukaryota | |
| Mg2+ | dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity | eukaryota | |
| Mn2+ | can partially substitue Mg2+ | eukaryota | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | MKK1 phosphorylates and activates the MAP kinases ERK1 and ERK2 | eukaryota | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAPK kinase-1 | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | dependent on | eukaryota | |
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