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Literature summary for 2.7.11.4 extracted from

  • Tso, S.C.; Qi, X.; Gui, W.J.; Chuang, J.L.; Morlock, L.K.; Wallace, A.L.; Ahmed, K.; Laxman, S.; Campeau, P.M.; Lee, B.H.; Hutson, S.M.; Tu, B.P.; Williams, N.S.; Tambar, U.K.; Wynn, R.M.; Chuang, D.T.
    Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (2013), Proc. Natl. Acad. Sci. USA, 110, 9728-9733.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.4

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with (S)-alpha-chloro-phenylpropionic acid, hanging drop vapor diffusion method, using 12% (w/v) PEG-8000, 0.1 M Tris·HCl, pH 8.5, 1.3-1.5 M NaCl Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-chloro-3-phenylpropanoic acid
-
 Mus musculus
(2S)-2-chloro-3-phenylpropanoic acid
-
 Mus musculus
(R)-alpha-chloroisocaproate
-
 Mus musculus
(S)-alpha-chloroisocaproate
-
 Mus musculus
2-oxoisocaproate
-
 Mus musculus
Clofibric acid
-
 Mus musculus
Hydrocinnamic acid
-
 Mus musculus
methylhydrocinnamic acid
-
 Mus musculus
phenylacetate
-
 Mus musculus
phenylbutyrate
-
 Mus musculus
phenylpyruvic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Mus musculus
-
 ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O55028
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
-
 Mus musculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
BCKD kinase
-
 Mus musculus
BDK
-
 Mus musculus
branched-chain alpha-ketoacid dehydrogenase kinase
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0063
-
 at pH 7.5 and 25°C Mus musculus (2S)-2-chloro-3-phenylpropanoic acid
0.012
-
 at pH 7.5 and 25°C Mus musculus (R)-alpha-chloroisocaproate
0.0214
-
 at pH 7.5 and 25°C Mus musculus (2R)-2-chloro-3-phenylpropanoic acid
0.0338
-
 at pH 7.5 and 25°C Mus musculus methylhydrocinnamic acid
0.0431
-
 at pH 7.5 and 25°C Mus musculus Hydrocinnamic acid
0.0531
-
 at pH 7.5 and 25°C Mus musculus phenylbutyrate
0.0534
-
 at pH 7.5 and 25°C Mus musculus (S)-alpha-chloroisocaproate
0.0749
-
 at pH 7.5 and 25°C Mus musculus 2-oxoisocaproate
0.346
-
 at pH 7.5 and 25°C Mus musculus phenylpyruvic acid
0.812
-
 at pH 7.5 and 25°C Mus musculus Clofibric acid
1.27
-
 at pH 7.5 and 25°C Mus musculus phenylacetate