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Literature summary for 2.7.11.4 extracted from

  • Murakami, T.; Matsuo, M.; Shimizu, A.; Shimomura, Y.
    Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors (2005), J. Nutr. Sci. Vitaminol., 51, 48-50.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-Chloroisocaproate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
alpha-Ketoisocaproate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
alpha-ketoisovalerate inhibits the enzyme by releasing it from the BCKD complex via dissociation Rattus norvegicus
additional information clofibric acid and thiamine diphosphate do not affect the protein-protein interaction of BDK with the BCKD complex Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase Rattus norvegicus the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism Rattus norvegicus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
?
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase phosphorylation of the branched-chain alpha-keto acid dehydrogenase complex leads to its inactivation, BDK itself is regulated via protein-protein interaction with the BCKD complex Rattus norvegicus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
?

Synonyms

Synonyms Comment Organism
BDK
-
Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase kinase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus