Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-Chloroisocaproate | inhibits the enzyme by releasing it from the BCKD complex via dissociation | Rattus norvegicus | |
alpha-Ketoisocaproate | inhibits the enzyme by releasing it from the BCKD complex via dissociation | Rattus norvegicus | |
alpha-ketoisovalerate | inhibits the enzyme by releasing it from the BCKD complex via dissociation | Rattus norvegicus | |
additional information | clofibric acid and thiamine diphosphate do not affect the protein-protein interaction of BDK with the BCKD complex | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | Rattus norvegicus | the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | the enzyme catalyzes the regulatory inactivation of the rate limiting enzyme in branched-chain amino acid catabolism | Rattus norvegicus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? | |
ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase | phosphorylation of the branched-chain alpha-keto acid dehydrogenase complex leads to its inactivation, BDK itself is regulated via protein-protein interaction with the BCKD complex | Rattus norvegicus | ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BDK | - |
Rattus norvegicus |
branched-chain alpha-keto acid dehydrogenase kinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |