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Literature summary for 2.7.11.4 extracted from
- Branched-chain alpha-keto acid dehydrogenase kinase (2000), Methods Enzymol., 324, 162-178.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Chloroisohexanoate | 50% inhibition at 0.014 mM | Rattus norvegicus |  |
| Dichloroacetate | 50% inhibition at 1.8 mM | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44000 | 45000 | SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver enzyme, heart enzyme and recombinant enzyme expressed in Escherichia coli | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0268 | - |
liver enzyme | Rattus norvegicus |
| 0.0357 | 0.09 | heart enzyme, depending on purification method | Rattus norvegicus |
| 0.05 | - |
recombinant enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone II-S | - |
Rattus norvegicus | ? | - |
? | |
| ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] | - |
Rattus norvegicus | ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate | - |
? | |
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Release 2023.1 (January 2023)
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