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Literature summary for 2.7.11.4 extracted from

  • Lau, K.S.; Cooper, A.J.L.; Chuang, D.T.
    Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates (1990), Biochim. Biophys. Acta, 1038, 360-366.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-Thienyl)-2-oxo-3-butenoate 2 mM Bos taurus
4-(3-Thienyl)-2-oxo-3-butenoate 2 mM Bos taurus
Furfurylidenepyruvate 1.85 mM Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus regulatory enzyme of branched-chain 2-oxoacid dehydrogenase complex ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Bos taurus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] regulatory enzyme of branched-chain 2-oxoacid dehydrogenase complex Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?
ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Bos taurus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.5
-
Furfurylidenepyruvate
-
Bos taurus