Literature summary for 2.7.11.31 extracted from

Hawley, S.A.; Selbert, M.A.; Goldstein, E.G.; Edelman, A.M.; Carling, D.; Hardie, D.G.
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms (1995), J. Biol. Chem., 270, 27186-27191.

Search for more literature for 2.7.11.31

Activating Compound

Activating Compound	Comment	Organism	Structure
5'-AMP	regulated by allosteric activation	Rattus norvegicus
additional information	activated by phosphorylation by upstream protein kinases AMPKK and CaMKIK	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]	Rattus norvegicus	bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes	ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]	-	Rattus norvegicus	ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate	-	?
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]	bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes	Rattus norvegicus	ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)