Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5'-AMP | - |
Rattus norvegicus | |
additional information | not activated by cAMP | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-fluorosulfonylbenzoyladenosine | - |
Rattus norvegicus | |
adenosine | - |
Rattus norvegicus | |
ADP | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | Rattus norvegicus Wistar | inactivates EC 1.1.1.34 by phosphorylation | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar | - |
Rattus norvegicus Wistar | - |
Wistar | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.069 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, in 0.05 M Tris-HCl, pH 7.5, 0.05 M NaF, 0.005 M diphosphate, 1 mM EDTA, 1 mM EGTA and 1 mM DTT, 0.1 mM PMSF, soybean trypsin inhibitor, benzamidine, Brij-35, 50% w/v glycerol, stable for at least 2 months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus Wistar | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | inactivates EC 1.1.1.34 by phosphorylation | Rattus norvegicus Wistar | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
additional information | acetyl-CoA carboxylase kinase EC 2.7.1.128 and hydroxymethylglutaryl-CoA reductase kinase activity are catalyzed by the same enzyme | Rattus norvegicus | ? | - |
? | |
additional information | acetyl-CoA carboxylase kinase EC 2.7.1.128 and hydroxymethylglutaryl-CoA reductase kinase activity are catalyzed by the same enzyme | Rattus norvegicus Wistar | ? | - |
? |