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Literature summary for 2.7.11.30 extracted from
- Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells (2008), Biochem. Biophys. Res. Commun., 377, 867-872.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient expression of wild-type and mutant enzymes in COS-7 cells, and in Min-6 and Hep-G2 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T194D | site-directed mutagenesis of ALK7 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calphostin C | - |
Homo sapiens |  |
| additional information | LY294002 completely abolishes the ALK7 mutant T194D/Smad3-induced synergistic effect by inhibiting interaction between the Smad3-Linker and PDX-1 | Homo sapiens | |
| PD98059 | - |
Homo sapiens | |
| Rapamycin | - |
Homo sapiens | |
| SB203580 | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [actividin receptor] | Homo sapiens | activins regulate pancreatic development, differentiation and insulin secretion, insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells, SBE and A/GG elements of the human insulin promoter are involved in the regulation of the ALK7 signal, regulation, overview | ADP + [actividin receptor] phosphate | - |
? | |
| additional information | Homo sapiens | ALK7 is a receptor for nodal and activin AB and B, overview. The insulin promoter is activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1, PDX-1, in the ALK7 pathway, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic beta cell | and beta cell lines | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [actividin receptor] | - |
Homo sapiens | ADP + [actividin receptor] phosphate | - |
? | |
| ATP + [actividin receptor] | activins regulate pancreatic development, differentiation and insulin secretion, insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells, SBE and A/GG elements of the human insulin promoter are involved in the regulation of the ALK7 signal, regulation, overview | Homo sapiens | ADP + [actividin receptor] phosphate | - |
? | |
| additional information | ALK7 is a receptor for nodal and activin AB and B, overview. The insulin promoter is activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1, PDX-1, in the ALK7 pathway, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activin receptor-like kinase 7 | - |
Homo sapiens |
| ALK7 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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