Any feedback?
Literature summary for 2.7.11.30 extracted from
- Smad2 phosphorylation by type I receptor. Contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity (2004), J. Biol. Chem., 279, 35781-35787.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TGF-beta | a potent regulator of cell proliferation, differentiation, motility, and apoptosis, binds to and activates serine/threonine receptors that phosphorylate Smad2 and Smad3 | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
| Mn2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | Mus musculus | - |
ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad3 | Mus musculus | - |
ADP + phosphorylated Smad3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| MEF cell | enbryonic fibroblast cell line | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Smad2 | - |
Mus musculus | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad2 | TGF-beta-induced phosphorylation of Arg462 and Cys463 by TbetaR-I, no activity with Smad2 mutant R462I/C463A by TbetaR-I, Smad2 is no substrate of TbetaR-II and BMP type II receptor | Mus musculus | ADP + phosphorylated Smad2 | - |
? | |
| ATP + Smad3 | - |
Mus musculus | ADP + phosphorylated Smad3 | - |
? | |
| ATP + Smad3 | TGF-beta-induced C-terminal phosphorylation | Mus musculus | ADP + phosphorylated Smad3 | - |
? | |
| additional information | substrate specificity of transforming growth factor-beta receptor I | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BMP type II receptor | - |
Mus musculus |
| BMPRII | - |
Mus musculus |
| serine/threonine receptor kinase | - |
Mus musculus |
| TbetaR-I | - |
Mus musculus |
| TbetaR-II | - |
Mus musculus |
| TGF-beta receptor | - |
Mus musculus |
| transforming growth factor-beta receptor | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
