Literature summary for 2.7.11.27 extracted from

Su, Y.W.; Lin, Y.H.; Pai, M.H.; Lo, A.C.; Lee, Y.C.; Fang, I.C.; Lin, J.; Hsieh, R.K.; Chang, Y.F.; Chen, C.L.
Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck (2014), PLoS ONE, 9, e96183.

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Activating Compound

Activating Compound	Comment	Organism	Structure
AMP	-	Homo sapiens
additional information	AMPK is activated in response to metabolic stresses, such as hypoxia and ischemia, and the anti-diabetic drug metformin	Homo sapiens

Application

Application	Comment	Organism
diagnostics	strong expression of phosphorylated acetyl-CoA carboxylase is an independent prognostic marker for patients with nodepositive of squamous cell carcinoma of the head and neck	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	in primary human tumor specimens	Homo sapiens	5737	-
nucleus	in healthy mucosa tissue	Homo sapiens	5634	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	Homo sapiens	-	ADP + [acetyl-CoA carboxylase] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	-	Homo sapiens	-
additional information	phosphorylated AMPK and phosphorylated acetyl-CoA carboxylase are mainly found in primary human tumor specimens	Homo sapiens	-
mucosa	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	-	Homo sapiens	ADP + [acetyl-CoA carboxylase] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Homo sapiens
AMPK	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine protein kinase	Homo sapiens
malfunction	phosphorylated enzyme AMPK is involved in impaired glucose metabolism, that increases the risk for squamous cell carcinoma of the head and neck (SCCHN) in humans	Homo sapiens
additional information	AMPK is activated in response to metabolic stresses, such as hypoxia and ischemia, and the anti-diabetic drug metformin	Homo sapiens
physiological function	AMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase (ACC). AMPK acts as a cellular fuel sensor by controlling intracellular energy levels to maintain appropriate cell growth rates. Phosphorylation and activation of AMPK stimulates fatty acid oxidation through the phosphorylation and subsequent inhibition of its downstream target acetyl-CoA carboxylase. Phosphorylated acetyl-CoA carboxylase may play a role in tumor progression of squamous cell carcinoma of the head and neck and may help to identify patient subgroups at high risk for poor disease outcome	Homo sapiens

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Release 2023.1 (January 2023)