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Literature summary for 2.7.11.27 extracted from

  • Wen, J.P.; Liu, C.E.; Hu, Y.T.; Chen, G.; Lin, L.X.
    Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus (2010), Mol. Cell. Biochem., 344, 109-115.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
adiponectin adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Mus musculus
-
ADP + [acetyl-CoA carboxylase] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q5EG47 AND Q8BRK8 subunit alpha-1 and subunit alpha-2
-

Source Tissue

Source Tissue Comment Organism Textmining
GT1-7 cell a mouse immortalized hypothalamic neuronal cell line Mus musculus
-
hypothalamus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
Mus musculus ADP + [acetyl-CoA carboxylase] phosphate
-
?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
Mus musculus
AMPK
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
metabolism globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway, but not the JAK/STAT3 pathway, in the hypothalamus. Adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA. Adiponectin had no effect on signal transducer and activator of transcription (STAT3), overview Mus musculus
physiological function AMP-activated protein kinase (AMPK) represents an energy sensor that responds to hormone and nutrition status in vivo and exerts a regulatory effect in the hypothalamus and multiple peripheral tissues. AMP-activated protein inhibits acetyl-CoA carboxylase (ACC) through phosphorylation Mus musculus