Activating Compound | Comment | Organism | Structure |
---|---|---|---|
adiponectin | adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | Mus musculus | - |
ADP + [acetyl-CoA carboxylase] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q5EG47 AND Q8BRK8 | subunit alpha-1 and subunit alpha-2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GT1-7 cell | a mouse immortalized hypothalamic neuronal cell line | Mus musculus | - |
hypothalamus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | - |
Mus musculus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Mus musculus |
AMPK | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway, but not the JAK/STAT3 pathway, in the hypothalamus. Adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA. Adiponectin had no effect on signal transducer and activator of transcription (STAT3), overview | Mus musculus |
physiological function | AMP-activated protein kinase (AMPK) represents an energy sensor that responds to hormone and nutrition status in vivo and exerts a regulatory effect in the hypothalamus and multiple peripheral tissues. AMP-activated protein inhibits acetyl-CoA carboxylase (ACC) through phosphorylation | Mus musculus |