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Literature summary for 2.7.11.27 extracted from

  • Peterson, J.M.; Aja, S.; Wei, Z.; Wong, G.W.
    CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition (2012), J. Biol. Chem., 287, 1576-1587.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
CTRP1 protein activates AMP-activated protein kinase (AMPK), which inhibits acetyl-CoA carboxylase (ACC) through phosphorylation. CTRP1 has a direct effect on AMPK signaling, recombinant CTRP1 administration acutely stimulates muscle AMPKalpha and ACC phosphorylation in vivo Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Mus musculus
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] Mus musculus C57BL/6
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q5EG47 AND Q8BRK8 subunit alpha-1 and subunit alpha-2
-
Mus musculus C57BL/6 Q5EG47 AND Q8BRK8 subunit alpha-1 and subunit alpha-2
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle isolated soleus muscle Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
 Mus musculus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase]
-
 Mus musculus C57BL/6 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus recombinant CTRP1 acutely induces AMPKalpha and ACC phosphorylation in skeletal muscle up

General Information

General Information Comment Organism
physiological function CTRP1 protein, a regulator of fatty acid metabolism, enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition Mus musculus