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Literature summary for 2.7.11.27 extracted from
- Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase (1998), FEBS Lett., 422, 43-46.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | - |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-D-glucose 6-phosphate | - |
Rattus norvegicus |  |
| alpha-glycerophosphate | - |
Rattus norvegicus | |
| beta-Glycerophosphate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
SDS-PAGE, two bands | Rattus norvegicus |
| 65000 | - |
SDS-PAGE, two bands | Rattus norvegicus |
| 130000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetyl-CoA carboxylase] | Rattus norvegicus | - |
ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| epididymis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetyl-CoA carboxylase] | - |
Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
| ATP + [acetyl-CoA carboxylase] | no increase in acetyl-CoA carboxylase activity | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
| ATP + [acetyl-CoA carboxylase] | incorporates 0.6 mol phosphate per mol of carboxylase | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| I-peptide kinase | highly specific for acetyl-CoA carboxylase, binds selectively to the dimeric form | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10 | - |
beta-Glycerophosphate | - |
Rattus norvegicus | |
| 20 | - |
alpha-glycerophosphate | - |
Rattus norvegicus | |
| 30 | - |
alpha-D-glucose 6-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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