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Literature summary for 2.7.11.27 extracted from

  • Ottey, K.A.; Takhar, S.; Munday, M.R.
    Comparison of two cyclic-nucleotide-independent acetyl-CoA carboxylase kinase from lactating rat mammary gland: identification of the kinase responsible for acetyl-CoA inactivation in vivo (1989), Biochem. Soc. Trans., 17, 349-350.
No PubMed abstract available
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
AMP activates ACK3, no effect on ACK2 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
 gel filtration Rattus norvegicus
76000
-
 ACK2 Rattus norvegicus
105000
-
 gel filtration ACK3 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Rattus norvegicus phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] Rattus norvegicus ACK3 and not ACK2 appears to be responsible for acetyl-CoA carboxylase inactivation in lactating mammary gland ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 response to 24 h starvation and high fat feeding
-

Purification (Commentary)

Purification (Comment) Organism
partial purification of ACK2 and ACK3 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase] inactivation of carboxylase Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] ACK3 and not ACK2 appears to be responsible for acetyl-CoA carboxylase inactivation in lactating mammary gland Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
More cAMP-dependent protein kinase identified, that phosphorylates and inactivates acetyl-CoA carboxylase in vitro, but appears not to be involved in regulation in vivo Rattus norvegicus