Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CoA | inhibitory | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP | 7% inhibition at 0.8 mM | Rattus norvegicus | |
CoA | 16% inhibition at 0.1 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
76000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetyl-CoA carboxylase] | Rattus norvegicus | phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis | ADP + [acetyl-CoA carboxylase] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary gland | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.008 | - |
purified enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ATP-citrate lyase | - |
Rattus norvegicus | ADP + (ATP-citrate lyase) phosphate | - |
? | |
ATP + casein | - |
Rattus norvegicus | ADP + phosphocasein | - |
? | |
ATP + glycogen synthase | - |
Rattus norvegicus | ADP + (glycogen synthase) phosphate | - |
? | |
ATP + histone | histone H1 and H2B, very high activity with histone H2B | Rattus norvegicus | ADP + phosphohistone | - |
? | |
ATP + phosphorylase kinase | poor substrate | Rattus norvegicus | ADP + (phosphorylase kinase) phosphate | - |
? | |
ATP + phosvitin | - |
Rattus norvegicus | ADP + phosvitin phosphate | - |
? | |
ATP + pyruvate kinase L | very poor substrate | Rattus norvegicus | ADP + (pyruvate kinase L) phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | inactivation of carboxylase | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | incorporates 1.5 mol phosphate per mol of carboxylase | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
ATP + [acetyl-CoA carboxylase] | phosphorylates and inactivates acetyl-CoA carboxylase, (EC 6.4.1.2), and is therefore involved in regulation of long chain fatty acid synthesis | Rattus norvegicus | ADP + [acetyl-CoA carboxylase] phosphate | - |
? | |
additional information | no activity with phosphorylase b | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | phosphorylation by cAMP-dependent protein kinase has the same effect on acetyl-CoA carboxylase activity then phosphorylation with acetyl-CoA carboxylase kinase-2 | Rattus norvegicus |
More | two other cAMP-independent kinases found, that phosphorylate but do not effect acetyl-CoA carboxylase kinase activity | Rattus norvegicus |