Cloned (Comment) | Organism |
---|---|
expressed as native and mutant FLAG-tag/HA-tag fusion protein in HEK293T cells, coexpression expreiments with TAK1 | Mus musculus |
expressed together with or without MEKK3 in HEK293T cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S526A/K391M | critical phosphorylation site and catalytic site | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inactive in vivo when bound to MEKK3; inactive in vivo when bound to TAK1 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | induces activation of NF-kappaB reporter activity, deficiency cells show defects in TNFalpha signalling | ? | - |
? | |
additional information | Mus musculus | involved in the activation of NF-kappaB, negatively regulates MEKK3-induced activation of NF-kappaB reporter activity, able to autophosphorylate at multiple sites when bound to TAB1, deficiency cells show defects in TNFalpha signalling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
activity requires TAB1 (TAK1 binding protein), binding of TAB1 promotes autophosphorylation of TAK1 | - |
Purification (Comment) | Organism |
---|---|
recombinant protein by tandem affinity purification | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | induces activation of NF-kappaB reporter activity, deficiency cells show defects in TNFalpha signalling | Mus musculus | ? | - |
? | |
additional information | involved in the activation of NF-kappaB, negatively regulates MEKK3-induced activation of NF-kappaB reporter activity, able to autophosphorylate at multiple sites when bound to TAB1, deficiency cells show defects in TNFalpha signalling | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEKK3 | belongs to the family of serine/threonine kinases | Mus musculus |
mitogen-activated protein/ERK kinase kinase 3 | - |
Mus musculus |
TAK1 | belongs to the family of serine/threonine kinases | Mus musculus |
TGFalpha activated kinase | - |
Mus musculus |