Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CpG | ASK1, TAK1, MEKK3 | Mus musculus | |
H2O2 | ASK1 | Mus musculus | |
interleukin 1 | TPL-2, TAK1, MEKK1 and MEKK3 | Mus musculus | |
lipopolysaccharide | ASK1, TPL-2, TAK1, MEKK1 and MEKK3 | Mus musculus | |
protein CD40 | TPL-2 | Mus musculus | |
protein PGN | ASK1 | Mus musculus | |
protein pI:C | ASK1 | Mus musculus | |
protein TAB1 | positively regulates TAK1 activity | Mus musculus | |
protein TAB2 | positively regulates TAK1 activity | Mus musculus | |
protein TNF | ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
TAK1 expressed in HeLa cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ASK1-/- cells, are resistant to TNF-induced apoptosis, produce low levels of TNF after LPS injection and are resistant to LPS-induced septic shock. In macrophages from TPL-2 deficient mice, activation of ERK is blocked following TLR4, TLR2 or TNFR1 stimulation, whereas activation of p38 and JNK via these receptors is unaffected, LPS upregulation of TNF is reduced, are resistant to endotoxin shock induced by LPS and D-galactosamine. TAK1-/- mice die early in uterus. Mlk3-/- mice are viable. In Mekk1-/- mice, normal or blocked JNK activation induced by TNF and IL-1, discrepancy in two different studies. MEKK3-deficient mice, embryonic lethal, activation of JNK and p38 is blocked, but not of ERK by IL-1 and TLR4 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p105 | blocks the ability of TPL-2 to interact with and phosphorylate MEk | Mus musculus | |
p38 | negatively regulates tAK1 activation | Mus musculus | |
RNAi | - |
Homo sapiens | |
RNAi | knockdown of TAK1 impairs p38 and JNK activation by IL-1 and TNF | Mus musculus | |
thioredoxin | ASK1 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | TPL-2, TAK1 | Mus musculus | - |
dendritic cell | ASK1 | Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
HeLa cell | TAK1 | Homo sapiens | - |
JURKAT cell | MLK3 | Homo sapiens | - |
macrophage | TPL-2 and MEKK1 | Mus musculus | - |
MEF cell | ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 | Mus musculus | - |
SCHNEIDER-2 cell | TAK1 | Drosophila melanogaster | - |
splenocyte | ASK1 | Mus musculus | - |
uterus | TAK1 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | - |
Drosophila melanogaster | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | - |
Homo sapiens | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | TPL-2, TAK1, MEKK3 | Mus musculus | ADP + phosphorylated ERK | - |
? | |
ATP + JNK | - |
Drosophila melanogaster | ADP + phosphorylated JNK | - |
? | |
ATP + JNK | - |
Homo sapiens | ADP + phosphorylated JNK | - |
? | |
ATP + JNK | ASK1, TPL-2, TAK1, MLK3, MEKK3 | Mus musculus | ADP + phosphorylated JNK | - |
? | |
ATP + MKK3 | ASK1 | Mus musculus | ADP + phosphorylated MKK3 | - |
? | |
ATP + MKK4 | ASK1 | Mus musculus | ADP + phosphorylated MKK4 | - |
? | |
ATP + MKK6 | ASK1, TAK1 | Mus musculus | ADP + phosphorylated MKK6 | - |
? | |
ATP + p38 | - |
Drosophila melanogaster | ADP + phosphorylated p38 | - |
? | |
ATP + p38 | - |
Homo sapiens | ADP + phosphorylated p38 | - |
? | |
ATP + p38 | ASK1, TAK1 | Mus musculus | ADP + phosphorylated p38 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-Raf | - |
Mus musculus |
apoptosis signal-regulating kinase 1 | - |
Mus musculus |
ASK1 | - |
Mus musculus |
B-Raf | - |
Mus musculus |
DLK | - |
Mus musculus |
LZK | - |
Mus musculus |
MAP 3-kinase | - |
Drosophila melanogaster |
MAP 3-kinase | - |
Mus musculus |
MAP 3-kinase | - |
Homo sapiens |
MAP kinase kinase kinase | - |
Drosophila melanogaster |
MAP kinase kinase kinase | - |
Mus musculus |
MAP kinase kinase kinase | - |
Homo sapiens |
MAP3K6 | - |
Mus musculus |
MEK kinase 1 | - |
Mus musculus |
MEK kinase 3 | - |
Mus musculus |
MEKK1 | - |
Mus musculus |
MEKK2 | - |
Mus musculus |
MEKK3 | - |
Mus musculus |
MEKK4 | - |
Mus musculus |
MLK1 | - |
Mus musculus |
MLK2 | - |
Mus musculus |
MLK3 | - |
Drosophila melanogaster |
MLK3 | - |
Mus musculus |
MLK3 | - |
Homo sapiens |
MLK4 | - |
Mus musculus |
Mos | - |
Mus musculus |
Raf-1 | - |
Mus musculus |
TAK1 | - |
Drosophila melanogaster |
TAK1 | - |
Mus musculus |
TAK1 | - |
Homo sapiens |
TAO1-2 | - |
Mus musculus |
TPL-2 | - |
Mus musculus |
transforming growth factor beta-activated kinase 1 | - |
Drosophila melanogaster |
transforming growth factor beta-activated kinase 1 | - |
Mus musculus |
transforming growth factor beta-activated kinase 1 | - |
Homo sapiens |
tumour progression locus 2 | - |
Mus musculus |
ZAK | - |
Mus musculus |