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Literature summary for 2.7.11.25 extracted from

  • Symons, A.; Beinke, S.; Ley, S.C.
    MAP kinase kinase kinases and innate immunity (2006), Trends Immunol., 27, 40-48.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CpG ASK1, TAK1, MEKK3 Mus musculus
H2O2 ASK1 Mus musculus
interleukin 1 TPL-2, TAK1, MEKK1 and MEKK3 Mus musculus
lipopolysaccharide ASK1, TPL-2, TAK1, MEKK1 and MEKK3 Mus musculus
protein CD40 TPL-2 Mus musculus
protein PGN ASK1 Mus musculus
protein pI:C ASK1 Mus musculus
protein TAB1 positively regulates TAK1 activity Mus musculus
protein TAB2 positively regulates TAK1 activity Mus musculus
protein TNF ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
TAK1 expressed in HeLa cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ASK1-/- cells, are resistant to TNF-induced apoptosis, produce low levels of TNF after LPS injection and are resistant to LPS-induced septic shock. In macrophages from TPL-2 deficient mice, activation of ERK is blocked following TLR4, TLR2 or TNFR1 stimulation, whereas activation of p38 and JNK via these receptors is unaffected, LPS upregulation of TNF is reduced, are resistant to endotoxin shock induced by LPS and D-galactosamine. TAK1-/- mice die early in uterus. Mlk3-/- mice are viable. In Mekk1-/- mice, normal or blocked JNK activation induced by TNF and IL-1, discrepancy in two different studies. MEKK3-deficient mice, embryonic lethal, activation of JNK and p38 is blocked, but not of ERK by IL-1 and TLR4 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
p105 blocks the ability of TPL-2 to interact with and phosphorylate MEk Mus musculus
p38 negatively regulates tAK1 activation Mus musculus
RNAi
-
Homo sapiens
RNAi knockdown of TAK1 impairs p38 and JNK activation by IL-1 and TNF Mus musculus
thioredoxin ASK1 Mus musculus

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell TPL-2, TAK1 Mus musculus
-
dendritic cell ASK1 Mus musculus
-
fibroblast
-
Homo sapiens
-
HeLa cell TAK1 Homo sapiens
-
JURKAT cell MLK3 Homo sapiens
-
macrophage TPL-2 and MEKK1 Mus musculus
-
MEF cell ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 Mus musculus
-
SCHNEIDER-2 cell TAK1 Drosophila melanogaster
-
splenocyte ASK1 Mus musculus
-
uterus TAK1 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK
-
Drosophila melanogaster ADP + phosphorylated ERK
-
?
ATP + ERK
-
Homo sapiens ADP + phosphorylated ERK
-
?
ATP + ERK TPL-2, TAK1, MEKK3 Mus musculus ADP + phosphorylated ERK
-
?
ATP + JNK
-
Drosophila melanogaster ADP + phosphorylated JNK
-
?
ATP + JNK
-
Homo sapiens ADP + phosphorylated JNK
-
?
ATP + JNK ASK1, TPL-2, TAK1, MLK3, MEKK3 Mus musculus ADP + phosphorylated JNK
-
?
ATP + MKK3 ASK1 Mus musculus ADP + phosphorylated MKK3
-
?
ATP + MKK4 ASK1 Mus musculus ADP + phosphorylated MKK4
-
?
ATP + MKK6 ASK1, TAK1 Mus musculus ADP + phosphorylated MKK6
-
?
ATP + p38
-
Drosophila melanogaster ADP + phosphorylated p38
-
?
ATP + p38
-
Homo sapiens ADP + phosphorylated p38
-
?
ATP + p38 ASK1, TAK1 Mus musculus ADP + phosphorylated p38
-
?

Synonyms

Synonyms Comment Organism
A-Raf
-
Mus musculus
apoptosis signal-regulating kinase 1
-
Mus musculus
ASK1
-
Mus musculus
B-Raf
-
Mus musculus
DLK
-
Mus musculus
LZK
-
Mus musculus
MAP 3-kinase
-
Drosophila melanogaster
MAP 3-kinase
-
Mus musculus
MAP 3-kinase
-
Homo sapiens
MAP kinase kinase kinase
-
Drosophila melanogaster
MAP kinase kinase kinase
-
Mus musculus
MAP kinase kinase kinase
-
Homo sapiens
MAP3K6
-
Mus musculus
MEK kinase 1
-
Mus musculus
MEK kinase 3
-
Mus musculus
MEKK1
-
Mus musculus
MEKK2
-
Mus musculus
MEKK3
-
Mus musculus
MEKK4
-
Mus musculus
MLK1
-
Mus musculus
MLK2
-
Mus musculus
MLK3
-
Drosophila melanogaster
MLK3
-
Mus musculus
MLK3
-
Homo sapiens
MLK4
-
Mus musculus
Mos
-
Mus musculus
Raf-1
-
Mus musculus
TAK1
-
Drosophila melanogaster
TAK1
-
Mus musculus
TAK1
-
Homo sapiens
TAO1-2
-
Mus musculus
TPL-2
-
Mus musculus
transforming growth factor beta-activated kinase 1
-
Drosophila melanogaster
transforming growth factor beta-activated kinase 1
-
Mus musculus
transforming growth factor beta-activated kinase 1
-
Homo sapiens
tumour progression locus 2
-
Mus musculus
ZAK
-
Mus musculus