Activating Compound | Comment | Organism | Structure |
---|---|---|---|
progesterone | induces c-Mos expression | Xenopus sp. |
Application | Comment | Organism |
---|---|---|
medicine | gene amplification and corresponding increased Tpl-2 expression in some human breast cancers | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | MEKK1 knockdown in invasive human breast carcinoma cells leads to reduced uPA expression, cell migration, and invasiveness | Homo sapiens |
additional information | MEKK1-4 knockout mice, MEKK3 knockout is embryo-lethal, displaying inadequate fetal-maternal vascularization. MEKK4 knockout is largely perinatal lethal, and associated with defective neural tube closure, shows loss of JNK and p38 activation. MEKK1-2 knockouts are associated with impaired tissue remodeling associated with wound healing and homeostasis, expression of JunB and Fra-2 is markedly increased in MEKK1-deficient mouse fibroblasts. MLK3-deficient mice are viable and fertile with only a mild defect in the epidermal tissue of the dorsal midline. Mouse embryos deficient in either B-Raf or C-Raf die before day E12.5. A-Raf deficient mice die perinatally at 1-3 weeks of age. Tpl2-deficient mice are viable and appear indistinguishable from littermates, produce reduced levels of TNFalpha in response to LPS injection, are resistant to LPS/D-galactosamine-induced pathology. TAK1-deficient mouse embryo fibroblasts show decreased IL-1beta-induced IL-6 expression, TAK1-deficient keratinocytes develop a severe postnatal inflammation, loss of MEKK1 does not alter the course of tumorigenesis or inhibit primary tumor growth, intimal hyperplasia is significantly reduced | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BAY 43-9006 | c-Raf inhibitor, shows promising response rate in patients with primary renal cell carcinomas | Homo sapiens | |
CEP-1347 | inhibits MLKs and is well tolerated in human trials, does not perform in trials for neurodegenerative disorders such as Parkinson´s disease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Xenopus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast carcinoma cell | - |
Homo sapiens | - |
carcinoma cell line | A-Raf is rarely mutated in human cancers | Homo sapiens | - |
embryo | - |
Mus musculus | - |
fibroblast | constitutive c-Mos expression transforms fibroblasts | Mus musculus | - |
keratinocyte | - |
Mus musculus | - |
MOLT-4 cell | mutated A-Raf | Homo sapiens | - |
oocyte | - |
Xenopus sp. | - |
renal cell carcinoma cell | c-Raf | Homo sapiens | - |
thymoma cell | Tpl-2 isolated from Moloney leukemia virus-induced thymoma cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK5 | - |
Mus musculus | ADP + phosphorylated ERK5 | - |
? | |
additional information | MEKK3 is required for IL-1R and LPS-induced IL-6 production in fibroblasts | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-Raf | - |
Mus musculus |
B-Raf | - |
Mus musculus |
c-mos | - |
Mus musculus |
c-mos | - |
Xenopus sp. |
C-Raf | - |
Mus musculus |
C-Raf | - |
Homo sapiens |
MEKK1 | - |
Mus musculus |
MEKK1 | - |
Homo sapiens |
MEKK2 | - |
Mus musculus |
MEKK2 | - |
Homo sapiens |
MEKK3 | - |
Mus musculus |
MEKK3 | - |
Homo sapiens |
MEKK4 | - |
Mus musculus |
MEKK4 | - |
Homo sapiens |
mitogen-activated protein kinase kinase kinase | - |
Mus musculus |
mitogen-activated protein kinase kinase kinase | - |
Homo sapiens |
mitogen-activated protein kinase kinase kinase | - |
Rattus norvegicus |
mitogen-activated protein kinase kinase kinase | - |
Xenopus sp. |
MKKK | - |
Mus musculus |
MKKK | - |
Homo sapiens |
MKKK | - |
Rattus norvegicus |
MKKK | - |
Xenopus sp. |
MKL3 | - |
Mus musculus |
MLK | - |
Homo sapiens |
TAK1 | - |
Mus musculus |
TPL-2 | - |
Mus musculus |
TPL-2 | - |
Homo sapiens |
TPL-2 | - |
Rattus norvegicus |