Application | Comment | Organism |
---|---|---|
additional information | MEKK1 negatively regulates temperature-sensitive and tissue-specific cell death and H2O2 accumulation that are partly dependent on both RAR1, a key component in resistance protein function, and SID2, an isochorismate synthase required for salicylic acid production upon pathogen infection | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mekk1-1 and mekk1-2 mutants, exhibit dwarfism and lethality, and also showed early senescence in cotyledons, loss of MEKK1 results in tissue-specific cell death, tissue-specific H2O2 accumulation and constitutive defense responses. Little or no suppression of dwarfism in mekk1/edm1 or mekk1/rar1 double mutants compared with mekk1 when grown at 22°C, but dwarf phenotype is highly recovered in mekk1/rar1 at 26°C, whereas mekk1/edm1 plants are only slightly bigger than mekk1. In mekk1/sid2 mutants growth defect, cell death, H2O2 accumulation and callose deposition phenotypes are not suppressed at 22°C. However, similar to rar1, sid2 partially suppresses these mekk1 phenotypes at 26°C, although the suppression effect is not as strong as in rar1 | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | suppression of mekk1 phenotypes at high temperature | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q39008 | Col ecotype | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cotyledon | preferential expression of MEKK1 in the vasculature | Arabidopsis thaliana | - |
leaf | preferential expression of MEKK1 in the vasculature | Arabidopsis thaliana | - |
vascular tissue | predominant expression of MEKK1 | Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + MPK4 | MEKK1 is essential for MPK4 activation by flg22 | Arabidopsis thaliana | ADP + phosphorylated MPK4 | - |
? | |
ATP + myelin basic protein | - |
Arabidopsis thaliana | ADP + phosphorylated myelin basic protein | - |
? | |
additional information | MEKK1 is dispensable for MPK3 and MPK6 activation by flg22 | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEKK1 | - |
Arabidopsis thaliana |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | 28 | - |
Arabidopsis thaliana |