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Literature summary for 2.7.11.25 extracted from

  • Ichimura, K.; Casais, C.; Peck, S.C.; Shinozaki, K.; Shirasu, K.
    MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis (2006), J. Biol. Chem., 281, 36969-36976.
    View publication on PubMed

Application

Application Comment Organism
additional information MEKK1 negatively regulates temperature-sensitive and tissue-specific cell death and H2O2 accumulation that are partly dependent on both RAR1, a key component in resistance protein function, and SID2, an isochorismate synthase required for salicylic acid production upon pathogen infection Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information mekk1-1 and mekk1-2 mutants, exhibit dwarfism and lethality, and also showed early senescence in cotyledons, loss of MEKK1 results in tissue-specific cell death, tissue-specific H2O2 accumulation and constitutive defense responses. Little or no suppression of dwarfism in mekk1/edm1 or mekk1/rar1 double mutants compared with mekk1 when grown at 22°C, but dwarf phenotype is highly recovered in mekk1/rar1 at 26°C, whereas mekk1/edm1 plants are only slightly bigger than mekk1. In mekk1/sid2 mutants growth defect, cell death, H2O2 accumulation and callose deposition phenotypes are not suppressed at 22°C. However, similar to rar1, sid2 partially suppresses these mekk1 phenotypes at 26°C, although the suppression effect is not as strong as in rar1 Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
additional information suppression of mekk1 phenotypes at high temperature Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q39008 Col ecotype
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Source Tissue

Source Tissue Comment Organism Textmining
cotyledon preferential expression of MEKK1 in the vasculature Arabidopsis thaliana
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leaf preferential expression of MEKK1 in the vasculature Arabidopsis thaliana
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vascular tissue predominant expression of MEKK1 Arabidopsis thaliana
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MPK4 MEKK1 is essential for MPK4 activation by flg22 Arabidopsis thaliana ADP + phosphorylated MPK4
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?
ATP + myelin basic protein
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Arabidopsis thaliana ADP + phosphorylated myelin basic protein
-
?
additional information MEKK1 is dispensable for MPK3 and MPK6 activation by flg22 Arabidopsis thaliana ?
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?

Synonyms

Synonyms Comment Organism
MEKK1
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Arabidopsis thaliana

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
22 28
-
Arabidopsis thaliana