Application | Comment | Organism |
---|---|---|
medicine | stress kinase MEKK1-induced MMP-1 expression in human arthritis-affected synovial cells is mediated, in large part, by c/EBPbeta (NF-kappaBp65) promoter transactivation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | prostaglandin E2, wild-type p53 expression in the presence of prostaglandin E2, and p53S15E suppress steady-state levels of MEKK1-induced interstitial collagenase MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. Prostaglandin E2, overexpression of p53wt with prostaglandin E2, or p53S15E abolish MEKK1-induced MMP-1 promoter luciferase activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synovial fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MEKK1-induced MMP-1promoter-driven luciferase activity is largely dependent on a c/EBPbeta-NF-kappaB-like enhancer site at -2008 to -1972 bp | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEKK1 | - |
Homo sapiens |