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Literature summary for 2.7.11.25 extracted from

  • Faour, W.H.; He, Q.; Mancini, A.; Jovanovic, D.; Antoniou, J.; Di Battista, J.A.
    Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expression (2006), J. Biol. Chem., 281, 19849-19860.
    View publication on PubMed

Application

Application Comment Organism
medicine stress kinase MEKK1-induced MMP-1 expression in human arthritis-affected synovial cells is mediated, in large part, by c/EBPbeta (NF-kappaBp65) promoter transactivation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information prostaglandin E2, wild-type p53 expression in the presence of prostaglandin E2, and p53S15E suppress steady-state levels of MEKK1-induced interstitial collagenase MMP-1 mRNA, effects nullified with co-transfection of p53 dnm or p53S15A. Prostaglandin E2, overexpression of p53wt with prostaglandin E2, or p53S15E abolish MEKK1-induced MMP-1 promoter luciferase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
synovial fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MEKK1-induced MMP-1promoter-driven luciferase activity is largely dependent on a c/EBPbeta-NF-kappaB-like enhancer site at -2008 to -1972 bp Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MEKK1
-
Homo sapiens