Literature summary for 2.7.11.25 extracted from

Oetjen, E.; Blume, R.; Cierny, I.; Schlag, C.; Kutschenko, A.; Kraetzner, R.; Stein, R.; Knepel, W.
Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells (2007), Diabetologia, 50, 1678-1687.

Search for more literature for 2.7.11.25

Application

Application	Comment	Organism
medicine	IL-1beta through MEKK1 inhibits human insulin gene transcription and does so, at least in part, by decreasing MafA transcriptional activity at the RIPE3b control element. Since inappropriate insulin biosynthesis contributes to beta cell dysfunction, inhibition of MEKK1 may decelerate or prevent progression from a prediabetic state to diabetes mellitus	synthetic construct

Cloned(Commentary)

Cloned (Comment)	Organism
expression vector for the catalytic domain of MEKK1 expressed in a beta cell line or in primary pancreatic islets from transgenic mice	synthetic construct

Inhibitors

Inhibitors	Comment	Organism	Structure
SB203580	does not relieve the inhibitory effect of MEKK1 on insulin gene transcription, although it effectively decreases phosphorylation of JNK, SAPK/p38 or ERK, respectively	synthetic construct
SP600125	does not relieve the inhibitory effect of MEKK1 on insulin gene transcription, although it effectively decreases phosphorylation of JNK, SAPK/p38 or ERK, respectively	synthetic construct
U0126	does not relieve the inhibitory effect of MEKK1 on insulin gene transcription, although it effectively decreases phosphorylation of JNK, SAPK/p38 or ERK, respectively	synthetic construct

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
MEKK1	-	synthetic construct
mitogen-activated protein kinase kinase kinase 1	-	synthetic construct

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Release 2023.1 (January 2023)