Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.25 extracted from

  • Stevens, M.V.; Parker, P.; Vaillancourt, R.R.; Camenisch, T.D.
    MEKK4 regulates developmental EMT in the embryonic heart (2006), Dev. Dyn., 235, 2761-2770.
    View publication on PubMed
Search for more literature for 2.7.11.25

Application

Application Comment Organism
medicine MEKK4 is a critical signaling molecule during cardiovascular development, plays an important role in cardiac cushion morphogenesis, kinase activity of MEKK4 is essential, but not sufficient, to support developmental epithelial to mesenchymal transformation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
into pBluescript, SF-9 insect cells infected with baculovirus expressing either MEKK4 or the kinase inactive form of MEKK4 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information kinase inactive form of MEKK4, attenuates mesenchyme production Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo MEKK4 mRNA is detected from stages embryonic day 8.5 through 14.5 encompassing prelooped, looping, cushion morphogenesis, and completed septation stages of heart development. MEKK4 protein is detected to the developing heart at stages embryonic day 10.5 to 14.5 Mus musculus
-
endothelial cell
-
 Mus musculus
-
heart detection of MEKK4 transcripts to early myocardium, endocardium and to cardiac cushion cells that have executed epithelial to mesenchymal transformation Mus musculus
-
heart ventricle
-
 Mus musculus
-
mesenchyme
-
 Mus musculus
-
additional information atrioventricular canal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MKK6
-
 Mus musculus ADP + phosphorylated MKK6
-
 ?

Synonyms

Synonyms Comment Organism
MAP kinase kinase kinase
-
 Mus musculus
MEKK4
-
 Mus musculus