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Literature summary for 2.7.11.25 extracted from

  • Du, J.; Cai, S.; Suzuki, H.; Akhand, A.A.; Ma, X.; Takagi, Y.; Miyata, T.; Nakashima, I.; Nagase, F.
    Involvement of MEKK1/ERK/p21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal (2003), J. Cell. Biochem., 88, 1235-1246.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
methylglyoxal induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes Mus musculus
methylglyoxal induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes Homo sapiens
additional information no effect on enzyme activity by RAF-1 Mus musculus
additional information no effect on enzyme activity by RAF-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by LY294002 or bisindolylmaleimide Homo sapiens
additional information no inhibition by LY294002 or bisindolylmaleimide Mus musculus
PD98059
-
Homo sapiens
PD98059
-
Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ERK Mus musculus PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated ERK
-
?
ATP + ERK Homo sapiens PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated ERK
-
?
ATP + MEK Mus musculus PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated MEK
-
?
ATP + MEK Homo sapiens PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway ADP + phosphorylated MEK
-
?
additional information Mus musculus alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest ?
-
?
additional information Homo sapiens alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell embryonic kidney cell line Homo sapiens
-
NIH-3T3 cell fibroblast cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK
-
Mus musculus ADP + phosphorylated ERK
-
?
ATP + ERK
-
Homo sapiens ADP + phosphorylated ERK
-
?
ATP + ERK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Mus musculus ADP + phosphorylated ERK
-
?
ATP + ERK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Homo sapiens ADP + phosphorylated ERK
-
?
ATP + MEK
-
Mus musculus ADP + phosphorylated MEK
-
?
ATP + MEK
-
Homo sapiens ADP + phosphorylated MEK
-
?
ATP + MEK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Mus musculus ADP + phosphorylated MEK
-
?
ATP + MEK PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway Homo sapiens ADP + phosphorylated MEK
-
?
ATP + MKK4 a MAPKK Mus musculus ADP + phosphorylated MKK4
-
?
ATP + MKK4 a MAPKK Homo sapiens ADP + phosphorylated MKK4
-
?
additional information alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest Mus musculus ?
-
?
additional information alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MEK kinase 1
-
Mus musculus
MEK kinase 1
-
Homo sapiens
MEKK1
-
Mus musculus
MEKK1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens