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Literature summary for 2.7.11.25 extracted from
- Dimerization through the catalytic domain is essential for MEKK2 activation (2005), J. Biol. Chem., 280, 13477-13482.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dimerization through the catalytic domain is essential for MEKK2 activation | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of GST-tagged full length MEKK2 and MEKK2 C-terminal and N-terminal fragments, i.e. of residues 1-619, 342-619, and 342-424, in COS-1 cells | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + MKK | Mus musculus | induction of the JNK pathway activation | ADP + phosphorylated MKK | - |
? | |
| additional information | Mus musculus | the enzyme is part of the MAPK signaling cascades, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + MKK | a MAPKK | Mus musculus | ADP + phosphorylated MKK | - |
? | |
| ATP + MKK | induction of the JNK pathway activation | Mus musculus | ADP + phosphorylated MKK | - |
? | |
| additional information | the enzyme is part of the MAPK signaling cascades, overview | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | dimerization through the catalytic domain is essential for MEKK2 activation, the dimerization motif is in the catalytic domain, the N-terminal domain is not required for dimerization, overview | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MEKK2 | - |
Mus musculus |
| MEKK3 | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Mus musculus |
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