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Literature summary for 2.7.11.25 extracted from

  • Samanta, A.K.; Huang, H.J.; Bast, R.C., Jr.; Liao, W.S.
    Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB (2004), J. Biol. Chem., 279, 7576-7583.
    View publication on PubMed
Search for more literature for 2.7.11.25

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of HA-tagged MEKK3 in HEK293, U373, and Hep3B cells, the expression of MEKK3 blocks the TRAIL-mediated activation of the apoptosis pathway and increases cell resistance to cytotoxic agents such as doxorubicin, daunorubicin, camptothecin, and paclitaxel, overview, TRAIL is a TNF-related apoptosis-inducing ligand Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information MEKK3 overexpression confers resistance to apoptosis through activation of NF-kappaB Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MEKK3 is involved in activation of NF-kappaB and increased expression of cell survival factors which confers resistance to apoptosis ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell high expression level of MEKK3 Homo sapiens
-
neuroglioma cell
-
 Homo sapiens
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ovarian cancer cell high expression level of MEKK3 Homo sapiens
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ovary
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MEKK3 is involved in activation of NF-kappaB and increased expression of cell survival factors which confers resistance to apoptosis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MEKK3
-
 Homo sapiens
mitogen-activated protein kinase/extracellular-regulated kinase kinase kinase-3
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 Homo sapiens