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Literature summary for 2.7.11.25 extracted from

  • Poitras, L.; Bisson, N.; Islam, N.; Moss, T.
    A tissue restricted role for the Xenopus Jun N-terminal kinase kinase kinase MLK2 in cement gland and pronephric tubule differentiation (2003), Dev. Biol., 254, 200-214.
    View publication on PubMed
Search for more literature for 2.7.11.25

Activating Compound

Activating Compound Comment Organism Structure
GTPAse Rac1 interacts with MLK2, the enzyme contains a G-protein binding domain, i.e. a CRIB domain Xenopus laevis
additional information UV irradiation increases the enzyme activity, no interaction with Cdc42 and RhoA by MLK2 Xenopus laevis

Cloned(Commentary)

Cloned (Comment) Organism
expression in embryos by microinjection in the two-cell stage, overexpression of MLK2 in COS-7 cells leading to a SEK1/MKK4-dependent hyperactivation of Jun N-terminal kinase Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information enzyme inactivation by antisense expression method and expression of dominant negative MLK2 defective in the ATP binding site, which impairs the UV irradiation sensitivity, overview Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
additional information no interaction with Cdc42 and RhoA by MLK2 Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis MLK2 plays a tissue specific role and is required for cement gland development and nephritic tubule formation, MLK2 mediates the response of Jun N-terminal kinase JNK, i.e. stress-activated protein kinase 1 SAPK1, to UV irradiation ?
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 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Xenopus laevis
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cement gland MLK2 expression correlates with cell elongation and the onset of an apoptotic phase Xenopus laevis
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additional information tissue-specific expression of MLK2, no or very low expression in liver, lung, heart, muscle, and kidney Xenopus laevis
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pancreas
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 Xenopus laevis
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pronephros embryo, MLK2 expression correlates with the differentiation and opening of the nephritic tubules, but not with apoptosis Xenopus laevis
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spleen
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 Xenopus laevis
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zygote MLK2 expression from late gastrula stage/early neurula stage on Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MLK2 plays a tissue specific role and is required for cement gland development and nephritic tubule formation, MLK2 mediates the response of Jun N-terminal kinase JNK, i.e. stress-activated protein kinase 1 SAPK1, to UV irradiation Xenopus laevis ?
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 ?

Synonyms

Synonyms Comment Organism
Jun N-terminal kinase kinase kinase
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 Xenopus laevis
MAPKKK
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 Xenopus laevis
MLK2
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 Xenopus laevis
More the enzyme belongs to the MLK family of mitogen activated protein kinase kinase kinases Xenopus laevis