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Literature summary for 2.7.11.25 extracted from

  • Zhou, L.; Tan, A.; Iasvovskaia, S.; Li, J.; Lin, A.; Hershenson, M.B.
    Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells (2003), Am. J. Respir. Cell Mol. Biol., 28, 762-769.
    View publication on PubMed
Search for more literature for 2.7.11.25

Activating Compound

Activating Compound Comment Organism Structure
additional information TNF-alpha induces MEKK1 and Ras activation Homo sapiens
Ras required for maximal activity in ERK and JNK phosphorylation/activation and for activation of AP-1 pathway Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ERK Homo sapiens i.e. extracellular signal-regulated kinase ADP + phosphorylated ERK
-
 ?
ATP + JNK Homo sapiens i.e. Jun amino terminal kinase ADP + phosphorylated JNK
-
 ?
additional information Homo sapiens regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
16HBE14o cell bronchial epithelial cell line Homo sapiens
-
bronchus
-
 Homo sapiens
-
epithelial cell bronchial Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ERK i.e. extracellular signal-regulated kinase Homo sapiens ADP + phosphorylated ERK
-
 ?
ATP + JNK i.e. Jun amino terminal kinase Homo sapiens ADP + phosphorylated JNK
-
 ?
additional information regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB Homo sapiens ?
-
 ?
additional information no phosphorylation/activation of IkappaB kinase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
extracellular signal-regulated kinase kinase kinase-1
-
 Homo sapiens
MAP kinase kinase kinase 1
-
 Homo sapiens
MEKK1
-
 Homo sapiens
mitogen-activated protein kinase kinase kinase-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens