Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TNF-alpha induces MEKK1 and Ras activation | Homo sapiens | |
Ras | required for maximal activity in ERK and JNK phosphorylation/activation and for activation of AP-1 pathway | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | Homo sapiens | i.e. extracellular signal-regulated kinase | ADP + phosphorylated ERK | - |
? | |
ATP + JNK | Homo sapiens | i.e. Jun amino terminal kinase | ADP + phosphorylated JNK | - |
? | |
additional information | Homo sapiens | regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
16HBE14o cell | bronchial epithelial cell line | Homo sapiens | - |
bronchus | - |
Homo sapiens | - |
epithelial cell | bronchial | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | i.e. extracellular signal-regulated kinase | Homo sapiens | ADP + phosphorylated ERK | - |
? | |
ATP + JNK | i.e. Jun amino terminal kinase | Homo sapiens | ADP + phosphorylated JNK | - |
? | |
additional information | regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB | Homo sapiens | ? | - |
? | |
additional information | no phosphorylation/activation of IkappaB kinase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
extracellular signal-regulated kinase kinase kinase-1 | - |
Homo sapiens |
MAP kinase kinase kinase 1 | - |
Homo sapiens |
MEKK1 | - |
Homo sapiens |
mitogen-activated protein kinase kinase kinase-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |