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Literature summary for 2.7.11.25 extracted from

  • Samejima, I.; Mackie, S.; Fantes, P.A.
    Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast (1997), EMBO J., 16, 6162-6170.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Schizosaccharomyces pombe required for activation of the MAPK homologue Spc1, and integrity of the Wis1-Spc1 pathway is required for survival in extreme conditions of heat, osmolarity, oxidation or limited nutrition. Phosphorylates Wis1 in vitro and activates it in vivo ADP + phosphoprotein
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?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O14299
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein required for activation of the MAPK homologue Spc1, and integrity of the Wis1-Spc1 pathway is required for survival in extreme conditions of heat, osmolarity, oxidation or limited nutrition. Phosphorylates Wis1 in vitro and activates it in vivo Schizosaccharomyces pombe ADP + phosphoprotein
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?
ATP + Wis1
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Schizosaccharomyces pombe ADP + phosphorylated Wis1
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?

Synonyms

Synonyms Comment Organism
MAP kinase kinase kinase wis4
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Schizosaccharomyces pombe