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Literature summary for 2.7.11.24 extracted from
- A selective small-molecule inhibitor of c-Jun N-terminal kinase 1 (2009), FEBS Lett., 583, 2208-2212.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ras | Ras induces phosphorylation of c-Jun by JNKs | Mus musculus | |
| Ras | Ras induces phosphorylation of c-Jun by JNKs | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | small-molecule inhibitors of JNK1 activity might be developed as therapeutics against diabetes | Mus musculus |
| medicine | small-molecule inhibitors of JNK1 activity might be developed as therapeutics against diabetes | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-(6-N-phenylaminohexyl)amino-2H-anthra[1,9-cd]pyrazol-6-one | AV-7 | Homo sapiens |  |
| 7-(6-N-phenylaminohexyl)amino-2H-anthra[1,9-cd]pyrazol-6-one | AV-7 | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P45983 | - |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Mus musculus |
| phosphoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + c-Jun | - |
Mus musculus | ADP + phosphorylated c-Jun | - |
? | |
| ATP + c-Jun | - |
Homo sapiens | ADP + phosphorylated c-Jun | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| c-jun N-terminal kinase 1 | - |
Mus musculus |
| c-jun N-terminal kinase 1 | - |
Homo sapiens |
| JNK1 | - |
Mus musculus |
| JNK1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
in vitro kinase assay | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the JNKs signal transduction pathway plays an important role in coordinating cellular responses including apoptosis, proliferation, and neoplastic transformation | Mus musculus |
| physiological function | the JNKs signal transduction pathway plays an important role in coordinating cellular responses including apoptosis, proliferation, and neoplastic transformation | Homo sapiens |
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Release 2023.1 (January 2023)
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