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Literature summary for 2.7.11.24 extracted from

  • Beretta, F.; Bassani, S.; Binda, E.; Verpelli, C.; Bello, L.; Galli, R.; Passafaro, M.
    The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells (2009), Eur. J. Neurosci., 30, 25-34.
    View publication on PubMed
Search for more literature for 2.7.11.24

Inhibitors

Inhibitors Comment Organism Structure
additional information GluR2 overexpression in U-87MG cells inhibits proliferation by inactivating extracellular signal-regulated kinase 1/2-Src phosphorylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MAPK
-
 Homo sapiens ADP + phosphorylated MAPK
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2
-
 Homo sapiens
extracellular signal-regulated kinase 1/2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.2 mM 6-nitro-7-sulfamoylbenzoquinoxaline decreases both p-ERK1/2 and p-Src Tyr416 levels in a time-dependent manner down
Homo sapiens 0.2 mM alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid increases both p-ERK1/2 and p-Src Tyr416 levels in a time-dependent manner up