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Literature summary for 2.7.11.24 extracted from

  • Chen, B.; Ma, Y.; Meng, R.; Xiong, Z.; Zhang, C.; Chen, G.; Zhang, A.; Dong, Y.
    MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals (2010), Acta Biochim. Biophys. Sin. (Shanghai), 42, 253-258.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information activated by phosphorylation Rattus norvegicus

Application

Application Comment Organism
medicine MG132 may be used as a pharmacological inhibitor of cardiac hypertrophy Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
MG132
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Sprague-Dawley rat
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2
-
 Rattus norvegicus
JNK1
-
 Rattus norvegicus
MAP kinase
-
 Rattus norvegicus
mitogen-activated kinase
-
 Rattus norvegicus
p38
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus