Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MAPKs are activated by phosphorylation through MAPK kinases, overview. TNF induces p38 MAP kinase, JNK is induced by TNF and lipopolysaccharide | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of mutant knockout p38alphaLPC-KO mice, hepatocyte-specific ablation of p38alpha in mice results in activation of MKK4 and MKK3/6 and excessive activation of JNK in the liver after in vivo challenge with bacterial lipopolysaccharide. Despite increased JNK activity, p38alpha-deficient hepatocytes are not sensitive to LPS/TNF toxicity showing that JNK activation is not sufficient to mediate TNF-induced liver damage. Lipopolysaccharide injection causes liver failure in mice lacking both p38alpha and IkappaB kinase 2 in hepatocytes, when combined with partial nuclear factor-kappaB inhibition, p38alpha deficiency sensitizes the liver to cytokine-induced damage | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview | ? | - |
? | |
additional information | Mus musculus C57BL/6 | activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P47811 | C57BL/6 mice | - |
Mus musculus C57BL/6 | P47811 | C57BL/6 mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | p38alpha MAPK are activated by phosphorylation through MAPK kinases, e.g. MKK3 and MKK6, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview | Mus musculus | ? | - |
? | |
additional information | activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun amino-terminal kinase | - |
Mus musculus |
JNK | - |
Mus musculus |
p38alpha MAPK | - |
Mus musculus |